Xiidra (Lifitegrast)

Xiidra (Lifitegrast) - Product Information

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What is XIIDRA used for?

XIIDRA is a prescription eye drop used to treat dry eye disease.

Dry eye happens when your eyes:

• Do not make enough tears, or
• Produce poor-quality tears

This can cause symptoms like burning, irritation, or a gritty feeling in the eyes.

How does XIIDRA work?

XIIDRA helps reduce inflammation (swelling) in the eyes.

It blocks certain proteins that contribute to irritation in dry eye disease, helping improve symptoms over time.

How to use XIIDRA

• Use 1 drop in each eye, twice daily (morning and evening, about 12 hours apart)
• Wash your hands before use
• Remove contact lenses before applying drops
• You can reinsert lenses after 15 minutes

Important tips:

• Each container is single-use only
• Use it for both eyes, then throw it away
• Do not touch the tip of the container to your eye

How quickly does it work?

Some patients notice improvement in symptoms as early as 2 weeks, but continue using it daily for best results.

Possible side effects

Common (usually mild and temporary):

• Eye irritation or discomfort
• Eye pain
• Blurred vision right after use
• Unusual taste in the mouth
• Redness or itchy eyes
• Increased tearing
• Headache or light sensitivity

Serious (rare – seek medical help immediately):

• Difficulty breathing
• Swelling of the tongue
• Severe allergic reaction

Warnings and precautions

Talk to your healthcare provider before using XIIDRA if you:

• Are pregnant or planning pregnancy
• Are breastfeeding

After using the drops:

• Your vision may be temporarily blurry
• Wait until vision clears before driving or using machinery

Missed dose

• Use it as soon as you remember
• If it’s close to your next dose, skip the missed one
• Do not double dose

Storage

• Store at 59–86°F
• Keep in original foil pouch to protect from light
• Discard opened containers immediately after use

Do not use XIIDRA if:

• You are allergic to lifitegrast or any ingredients in the product

Additional notes

• There are no known drug interactions
• Safe use in children has not been established
• Can be used alongside artificial tears if recommended by your provider

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Refernce: Xiidra Canada product monograph

Use Xiidra eye drops twice daily, about 12 hours apart. Wash hands before use. Instill one drop into each eye, avoiding contact with the dropper tip. Remove contact lenses before use and wait 15 minutes before reinserting. Do not reuse single-use containers.