Provera Tablets (Medroxyprogesterone)

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Provera Tablets (Medroxyprogesterone)

Medroxyprogesterone Acetate


Product information

Provera (medroxyprogesterone acetate) tablets, available in 2.5 mg, 5 mg, and 10 mg, are used for hormonal replacement therapy, treating menstrual disorders, and as additional treatment for endometrial and breast cancer. It balances estrogen effects, reducing uterine cancer risk. Common side effects include breast tenderness, headaches, and changes in menstrual flow. Regular check-ups are essential. Avoid use if pregnant or with certain health conditions.

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PROVERA - Canada Product Information



Provera contains a hormone called medroxyprogesterone acetate, similar to the natural hormone progesterone produced by your ovaries. It comes in tablet form and is available in three strengths: 2.5 mg, 5 mg, and 10 mg.


What is Provera used for?

Provera is used in women with an intact uterus for:

  • Hormonal replacement therapy to protect the lining of the uterus when taking estrogen.
  • Treating menstrual disorders due to hormonal imbalance in non-pregnant women.
  • Additional treatment to relieve symptoms of endometrial (lining of the uterus) and breast cancer.

How does Provera work?

Provera helps to balance the effects of estrogen, reducing the risk of overgrowth of the uterus lining and cancer. It also helps to regulate menstrual periods in non-pregnant women by decreasing the growth of the uterus lining and reducing bleeding.


Important Information

  • Serious Risks: Taking Provera with estrogen increases the risk of serious conditions such as stroke, heart attack, blood clots, and breast cancer. Use the lowest effective dose for the shortest time possible and have regular check-ups with your healthcare professional.
  • Do Not Use If: You have liver problems, certain cancers, unexplained vaginal bleeding, a history of blood clots or stroke, are pregnant or suspect you might be, or are allergic to any of the ingredients.

  • Before Taking Provera

    Inform your healthcare professional if you have:

    • A history of breast disease or cancer
    • Unusual vaginal bleeding
    • Liver disease or jaundice
    • High blood pressure, diabetes, or heart disease
    • A history of depression
    • Plans for surgery or long periods of inactivity

    How to Take Provera

  • Follow your healthcare professional’s instructions on dosage and duration.
  • Take Provera with or without food, at the same time each day.
  • If you miss a dose, take it as soon as you remember unless it’s almost time for your next dose. Do not double up on doses.

  • Possible Side Effects

    Common side effects include:

    • Breast tenderness
    • Headache or dizziness
    • Nausea or bloating
    • Changes in menstrual flow
    • Weight gain or fluid retention

    Report any unusual symptoms to your healthcare professional, such as severe headaches, vision changes, or unusual vaginal bleeding.


    Storage and Handling

    Store Provera at room temperature (59°F - 86°F).

    Keep out of reach of children.


    Regular Check-Ups

    Your healthcare professional will conduct regular exams, including breast exams and mammograms, to monitor your health while you are taking Provera. Ensure to report any new symptoms or changes in your health promptly.


    For any questions or more information about Provera, consult your healthcare professional.



    Reference: Provera Canada product monograph