Mounjaro Vials (Tirzepatide)

SAVE on MOUNJARO ordering online from Canada! (USA Prescription Required)

Mounjaro (Tirzepatide) - Canada Product Information

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A product video recording for Mounjaro vials may be seen here

HOW DOES MOUNJARO WORK?

Mounjaro is a medication used to help manage blood sugar levels in adults with type 2 diabetes. It is taken once a week by injection under the skin.

Mounjaro works by activating specific receptors in your body (GIP and GLP-1 receptors), which help to:

• Increase insulin release
• Decrease glucagon levels
• Slow down stomach emptying
• Reduce food intake

WHO SHOULD USE MOUNJARO?

Mounjaro is for adults with type 2 diabetes who need to improve their blood sugar levels. It can be used:

• Alone, if you cannot take metformin
• With other diabetes medications like metformin, sulfonylureas, SGLT2 inhibitors, or basal insulin

Note: Mounjaro is not for treating type 1 diabetes or diabetic ketoacidosis.

HOW TO USE MOUNJARO

• Starting Dose: Begin with 2.5 mg once a week.
• Adjusting Dose: After 4 weeks, increase to 5 mg once a week. If needed, increase by 2.5 mg increments every 4 weeks.
• Maximum Dose: Do not exceed 15 mg once a week.

Mounjaro Dosing Chart

INSTRUCTIONS:

• Inject under the skin of your abdomen, thigh, or upper arm.
• Rotate the injection site each week.
• Inspect the solution before use; it should be clear and colorless to slightly yellow.

A video on administration of Canadian Mounjaro is available here.

MISSED DOSE

If you miss a dose, take it as soon as you remember within 4 days (96 hours). If more than 4 days have passed, skip the missed dose and continue with your regular schedule.

POSSIBLE SIDE EFFECTS

Common side effects may include:

• Nausea
• Diarrhea
• Vomiting
• Decreased appetite

Serious side effects:

• Thyroid Tumors: Tell your doctor if you notice a lump in your neck, trouble swallowing, or persistent hoarseness.
• Pancreatitis: Seek medical help if you experience severe abdominal pain that doesn't go away.
• Gallbladder Issues: Watch for symptoms like severe stomach pain, fever, or yellowing of your skin/eyes.

SPECIAL PRECAUTIONS

• Pregnancy and Breastfeeding: Do not use Mounjaro if you are pregnant or breastfeeding.
• Kidney and Liver Problems: Inform your doctor if you have kidney or liver issues.
• Other Medications: Tell your doctor about all the medications you are taking, as Mounjaro can affect how they work.

STORAGE

• Store in a refrigerator
• If needed, Mounjaro can be kept at room temperature (up to 86°F) for up to 21 days.
• Do not freeze.

Always follow your doctor's instructions and have regular check-ups to monitor your diabetes management.

Reference: Mounjaro Canada product monograph

Mounjaro Vials for Americans: Product Video

Using Mounjaro for Weight Loss

Mounjaro (tirzepatide) is primarily approved for managing type 2 diabetes, but its potential for weight loss has garnered significant interest. This medication works by activating both GIP and GLP-1 receptors, which enhances insulin secretion, reduces glucagon levels, slows gastric emptying, and decreases appetite.

Clinical trials have demonstrated substantial weight loss in individuals taking Mounjaro, even those without diabetes. In studies, participants experienced significant reductions in body weight, with some losing over 10% of their initial body weight after several months of treatment. This makes Mounjaro an attractive option for obesity management, especially for those who have struggled with traditional weight loss methods.

Mounjaro's dual action mechanism helps to control hunger and promote a feeling of fullness, which can be particularly beneficial for individuals with obesity. By reducing caloric intake and improving metabolic functions, Mounjaro supports sustainable weight loss.

However, using Mounjaro for weight loss should be done under medical supervision. Potential side effects, such as nausea, diarrhea, and vomiting, should be monitored. While promising, more extensive studies are needed to fully understand the long-term effects and safety of Mounjaro for weight loss in non-diabetic individuals. Always consult a healthcare provider before starting any off-label medication use.

Advantages of Tirzepatide Over Semaglutide

Dual Receptor Agonism

One of the most significant advantages of tirzepatide over semaglutide is its unique dual receptor agonism. Tirzepatide activates both the Glucose-Dependent Insulinotropic Polypeptide (GIP) and Glucagon-Like Peptide-1 (GLP-1) receptors. This dual action results in enhanced insulin secretion, improved blood sugar control, and more significant weight loss compared to the single GLP-1 receptor agonism provided by semaglutide.

Superior Glycemic Control

Clinical trials have shown that tirzepatide offers superior glycemic control compared to semaglutide. In head-to-head studies, patients treated with tirzepatide achieved greater reductions in HbA1c levels, a key marker of long-term blood sugar control. This makes tirzepatide a more effective option for managing type 2 diabetes, particularly in patients who struggle to achieve target HbA1c levels with other treatments.

Greater Weight Loss

Tirzepatide has demonstrated superior weight loss outcomes in clinical trials compared to semaglutide. Patients using tirzepatide experienced more significant reductions in body weight, which is beneficial for both diabetes management and overall health. Effective weight loss contributes to better glycemic control, reduced cardiovascular risk, and improved quality of life.

Enhanced Cardiovascular Benefits

Tirzepatide’s dual mechanism may provide enhanced cardiovascular benefits. While both tirzepatide and semaglutide have shown potential in reducing cardiovascular events, tirzepatide’s broader metabolic effects, including more substantial weight loss and improved insulin sensitivity, could offer additional cardiovascular protection.