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Pharmaceutical Facts on Flovent MDI
| Category | Details |
|---|---|
| Generic Name | Fluticasone Propionate |
| Brand Name | Flovent HFA |
| Drug Class | Inhaled Corticosteroid |
| Indication | – Management of chronic respiratory conditions (asthma, bronchitis) in cats and dogs – Prevention of respiratory flare-ups in chronic cases |
| Other Indications | – Adjunctive therapy for long-term corticosteroid treatment of respiratory conditions in animals |
| Formulation | Inhaled aerosol (metered-dose inhaler) |
| Common Dosages | 44 mcg (50 mcg), 110 mcg (125 mcg), 220 mcg (250 mcg) per actuation |
| Mechanism of Action | Reduces inflammation in the airways, improving breathing and preventing asthma attacks in pets |
| Pharmacokinetics | – Absorption: Local action in lungs with limited systemic absorption – Half-life: Approx. 7.8 hours – Metabolism: Liver via CYP3A4 – Excretion: Bile and feces |
| Administration | – Administered via inhalation, typically twice daily – If missed dose, administer ASAP but do not double the next dose |
| Common Side Effects | – Coughing or gagging – Throat irritation – Sneezing – Minor weight gain – Increased appetite |
| Serious Side Effects | – Immune suppression, increasing infection risk – Adrenal insufficiency (long-term use) – Delayed wound healing – Behavioral changes |
| Contraindications | – Hypersensitivity to fluticasone or any component – Untreated fungal, bacterial, or viral infections |
| Special Populations | – Elderly Pets: Monitor for systemic corticosteroid effects – Pets with Pre-existing Conditions: Use cautiously – Young Pets: Safety not established for very young animals |
| Monitoring | – Regularly assess respiratory function – Monitor for signs of systemic corticosteroid effects and infections |
| Pregnancy Category | Use only if the potential benefit justifies the potential risk to the fetus in pregnant pets |
| Lactation | Excretion in animal milk unknown; use with caution in nursing pets |
| Drug Interactions | – Other corticosteroids: Risk of systemic effects – Diuretics: Risk of hypokalemia – Antifungals/antibiotics: May increase fluticasone levels |
| Overdose Management | – Symptomatic and supportive treatment – Monitor for adrenal insufficiency – Gradual dose tapering may be necessary |
| Special Precautions | – Avoid exposure to infectious agents – Monitor for behavioral changes or stress in pets |
| Storage | – Store at room temperature (20-25°C or 68-77°F) – Protect from moisture and sunlight – Keep out of reach of children and pets |
| Manufacturer | GlaxoSmithKline |
| Approval Year | Not applicable (veterinary use is off-label) |
| Market Availability | Available through veterinary prescription and online pharmacies |