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Living with Type 2 diabetes comes with its own set of challenges, impacting your daily routine and overall health. Invokana is designed to help control blood sugar levels and lower the risk of cardiovascular complications in adults with Type 2 diabetes. By improving glycemic control, Invokana supports you in managing your condition more effectively, allowing you to focus on leading a healthier life.

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Pharmaceutical Facts on Invokana Tablets

Category	Details
Brand Name	Invokana
Generic Name	Canagliflozin
Drug Class	SGLT2 Inhibitor (Sodium-Glucose Co-Transporter 2 Inhibitor)
Indication	Type 2 Diabetes Mellitus
Mechanism of Action	Invokana works by inhibiting the SGLT2 protein in the kidneys. SGLT2 is responsible for reabsorbing glucose back into the bloodstream. By blocking this protein, Invokana promotes the excretion of excess glucose through urine, thereby lowering blood sugar levels and aiding in diabetes management.
Dosage Forms	Oral Tablets – 100 mg – 300 mg
Usual Dosage	– Initial Dose: 100 mg taken once daily before the first meal of the day. – Maintenance Dose: The dose may be increased to 300 mg once daily if additional glycemic control is needed and the patient tolerates the lower dose with adequate renal function.
Common Side Effects	– Urinary tract infections (UTIs): Increased frequency of urination and discomfort. – Genital yeast infections: Itching, redness, and irritation. – Increased urination: Frequent need to urinate. – Thirst: Feeling unusually thirsty. – Constipation: Hard stools. – Nausea: Upset stomach.
Serious Side Effects	– Ketoacidosis: A serious condition involving high levels of acid in the blood. Symptoms include nausea, vomiting, abdominal pain, and confusion. – Acute kidney injury: Signs include reduced urine output and swelling in legs or feet. – Lower limb amputation: Rare but serious, often associated with infection or ulcers. – Hypoglycemia: Particularly when used with insulin or sulfonylureas. Symptoms include shaking, sweating, and confusion. – Hyperkalemia: High potassium levels, which can lead to muscle weakness and heart issues.
Contraindications	– Severe renal impairment: Including patients on dialysis. – Hypersensitivity: To canagliflozin or any other ingredients in Invokana.
Warnings & Precautions	– Renal Monitoring: Regularly assess kidney function before starting and during treatment. – Risk of Ketoacidosis: Be cautious during periods of reduced caloric intake, illness, or reduced insulin doses. – Lower Limb Amputation Risk: Advise patients on proper foot care and monitor for signs of infection.
Drug Interactions	– Diuretics: Increased risk of dehydration and hypotension. – Insulin or Insulin Secretagogues: Increased risk of hypoglycemia. – Digoxin: Can lead to increased exposure and potential toxicity.
Pregnancy Category	Category C: The potential risks cannot be ruled out. Invokana should only be used if the potential benefits justify the risks to the fetus.
Lactation	Not Recommended: It is not known if canagliflozin is excreted in human milk. Use caution and consider the benefits and risks before use in breastfeeding women.
Patient Counseling Information	– Hydration: Encourage patients to stay well-hydrated, especially in hot weather or during exercise. – Signs of Ketoacidosis: Educate patients on symptoms and advise them to seek immediate medical attention if they occur. – Foot Care: Stress the importance of regular foot inspections to prevent infections. – Blood Glucose Monitoring: Regular monitoring is essential to ensure effective management of blood sugar levels.
Storage	Storage Conditions: Store Invokana at room temperature, between 68°F to 77°F (20°C to 25°C), in the original container to protect from moisture.
Manufacturer	Janssen Pharmaceuticals
FDA Approval Date	March 29, 2013
Market Availability	Global Availability: Available in the USA, Canada, and many other countries worldwide.
Cost Considerations	Pricing: Costs vary depending on insurance coverage, pharmacy, and location. Savings may be substantial when ordered through online Canadian pharmacies like DrugsByCanada.com.