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Pharmaceutical Facts on Trintellix Tablets

Fact	Details
Medication Name	Trintellix (vortioxetine)
Drug Class	Serotonin Modulator
Purpose	Treatment of major depressive disorder (MDD)
Dosage Forms	Oral tablets
Available Strengths	5 mg, 10 mg, 20 mg tablets
How It Works	Modulates serotonin activity in the brain by working on multiple serotonin receptors and inhibiting the serotonin transporter. This helps improve mood, cognitive function, and overall mental health.
Common Side Effects	Nausea, headache, dizziness, diarrhea, dry mouth, constipation, vomiting, and abnormal dreams. These side effects are usually mild and tend to decrease over time as your body adjusts to the medication.
Serious Side Effects	Serotonin Syndrome (symptoms include agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea), Increased Risk of Suicidal Thoughts (especially in young adults, teenagers, and children), Mania or Hypomania (unusual changes in mood or behavior), Severe Allergic Reactions (swelling of the face, tongue, or throat, severe rash, difficulty breathing).
Starting Dose	Typically, 10 mg once daily. Your doctor may adjust the dose based on your response to treatment, potentially increasing it to 20 mg daily or lowering it to 5 mg if side effects are problematic.
Maximum Dose	The maximum recommended dose is 20 mg once daily.
Administration	Trintellix is taken once daily, with or without food. It is important to take it at the same time each day to maintain consistent levels in your bloodstream. Swallow the tablet whole; do not crush or chew it.
Time to Effect	It may take several weeks (typically 4-6 weeks) to feel the full effects of Trintellix. Some patients may notice improvements in mood and symptoms within the first two weeks, but it’s important to continue taking the medication as prescribed by your doctor.
Duration of Treatment	Treatment duration varies depending on the individual and the severity of the condition. It may be prescribed for several months to years. Do not discontinue use abruptly without consulting your doctor, as this can lead to withdrawal symptoms.
FDA Approval	Trintellix was approved by the FDA in September 2013 for the treatment of major depressive disorder in adults.
Pregnancy Category	Category C (Risk cannot be ruled out). There is limited data on the use of Trintellix during pregnancy. It should only be used if the potential benefits justify the potential risks to the fetus. Always consult with your healthcare provider.
Breastfeeding	It is unknown whether Trintellix is excreted in human breast milk. Women who are breastfeeding should consult their healthcare provider before using Trintellix.
Drug Interactions	Trintellix can interact with several medications, including MAOIs (do not use within 14 days of MAOI treatment), SSRIs/SNRIs, Triptans, Tramadol, NSAIDs, Blood Thinners (like warfarin), Lithium, and St. John’s Wort. These interactions can increase the risk of serotonin syndrome, bleeding, or other side effects. Always inform your doctor of all medications and supplements you are taking.
Alcohol Interaction	Alcohol can exacerbate the side effects of Trintellix, such as dizziness and drowsiness. It is generally advised to limit or avoid alcohol consumption while taking this medication.
Manufacturer	Trintellix is co-developed by Lundbeck and Takeda Pharmaceuticals.
Storage	Store at room temperature (between 68°F to 77°F or 20°C to 25°C). Keep the medication in its original container, away from moisture and heat. Ensure that the container is tightly closed when not in use. Keep out of reach of children.
Prescription Requirement	Trintellix is a prescription-only medication. A valid prescription from a healthcare provider is required to purchase this medication.
Special Populations	Elderly: Use with caution as older adults may be more sensitive to the side effects, especially dizziness and hyponatremia (low sodium levels). Pregnant/Breastfeeding Women: Consult your healthcare provider due to the potential risks involved. Liver/Kidney Impairment: Dose adjustment may be necessary; consult your healthcare provider.
Discontinuation	Gradual tapering is recommended to avoid withdrawal symptoms such as dizziness, irritability, nausea, and sensory disturbances. Never stop taking Trintellix abruptly without medical advice.
Patient Assistance Programs	Some patients may be eligible for assistance programs or savings cards offered by the manufacturer to help reduce the cost of Trintellix. Check with your healthcare provider or visit the manufacturer’s website for more information.
Cost Comparison	Trintellix can be expensive, especially without insurance. However, purchasing from Canadian pharmacies or using manufacturer coupons can significantly reduce the cost.
Monitoring	Regular follow-ups with your healthcare provider are important to monitor the effectiveness of the medication and manage any side effects. Blood tests may be required periodically to check for any adverse effects on the liver or electrolytes.
Alternative Medications	Other antidepressants include SSRIs (e.g., Prozac, Zoloft), SNRIs (e.g., Effexor, Cymbalta), Atypical Antidepressants (e.g., Wellbutrin, Remeron). Each class has different mechanisms of action and side effect profiles, and your doctor can help determine the best option for your condition.
Key Points to Remember	Trintellix is a unique antidepressant with a broad mechanism of action, potentially offering benefits for both mood and cognitive function. It is generally well-tolerated, but side effects can occur, particularly when starting or stopping the medication. Adherence to your prescribed regimen and open communication with your healthcare provider are crucial for successful treatment.