Calquence (Acalabrutinib)

Calquence® (Acalabrutinib) - Canada Product Information

What is Calquence®?

Calquence® is a medication containing the active ingredient acalabrutinib. It is used to treat certain types of blood cancers, including:

• Chronic Lymphocytic Leukemia (CLL): Used alone or in combination with other medications for patients who have not been treated before or who have already received treatment.
• Mantle Cell Lymphoma (MCL): For patients who have already received at least one treatment.

How Does Calquence® Work?

Calquence® works by blocking a protein in cancer cells called BTK (Bruton's tyrosine kinase). This protein is important for the survival and growth of these cancer cells. By blocking BTK, Calquence® helps to slow down or stop the growth of cancer cells.

How to Take Calquence®

• Dosage: The usual dose is one 100 mg tablet taken twice a day, about 12 hours apart.
• Administration: Swallow the tablet whole with water, at the same time every day. You can take it with or without food. Do not crush, chew, or dissolve the tablet.
• Missed Dose: If you miss a dose and it’s more than 3 hours late, just skip it. Take your next dose at the usual time. Do not double up on doses.

Important Safety Information

• Bleeding Risks: Calquence® may increase the risk of bleeding. If you notice unusual bruising, bleeding, or blood in your urine or stools, contact your healthcare provider immediately.
• Infections: This medication can make it easier for you to get infections. Report any signs of infection like fever, chills, or sore throat to your doctor right away.
• Heart Problems: In rare cases, Calquence® can cause irregular heartbeats. If you experience palpitations, dizziness, or chest pain, seek medical advice promptly.

Who Should Not Take Calquence®?

• Allergies: Do not take Calquence® if you are allergic to acalabrutinib or any other ingredients in the medication.
• Pregnancy: Do not use Calquence® if you are pregnant or planning to become pregnant. It may harm your unborn baby.
• Breastfeeding: It is not known if Calquence® passes into breast milk. Do not breastfeed during treatment and for 2 weeks after the last dose.

Possible Side Effects

Common side effects may include:

• Headache
• Diarrhea
• Muscle and joint pain
• Fatigue
• Nausea

Some serious side effects include:

• Severe infections
• Irregular heartbeats
• Severe bleeding

If you experience any severe side effects, contact your healthcare provider immediately.

Drug Interactions

Certain medications can affect how Calquence® works or increase the risk of side effects. Tell your doctor about all the medications you are taking, especially:

• Blood thinners
• Antibiotics
• Antifungal medications
• Herbal supplements like St. John’s wort

Storage

Store Calquence® at room temperature between 59°F and 86°F in its original container. Keep it out of reach of children.

Disposal

Dispose of unused or expired medication according to local regulations. Do not throw it in household trash or flush it down the toilet.

This is designed to give you a summary of Calquence®. Always follow your healthcare provider's instructions and read the patient information provided with the medication.

Reference: Calquence® Canada product monograph