U.K. Supply | Mounjaro KwikPen (Tirzepatide)

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Mounjaro KwikPen (Tirzepatide) - Product Information

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IMPORTANT NOTICE: In the United Kingdom, Mounjaro KwikPen is dispensed as a multi-dose prefilled pen, with each pen containing four weekly doses. One pen provides a full month (28 days) of medication, so only one pen is needed for a 28-day supply. Mounjaro KwikPens from U.K. are packaged with instructions for use and come in their original sealed packaging.

This differs from the United States, where Mounjaro is dispensed as single-use pens, with each pen containing only one weekly dose.

Understanding Mounjaro KwikPen for Type 2 Diabetes

Mounjaro KwikPen (tirzepatide) is an injectable medication designed to help adults with type 2 diabetes manage their blood sugar levels. It is typically used once a week and is meant to complement diet and exercise routines. Mounjaro may be used on its own or with other diabetes treatments, like metformin or basal insulin. For people with type 2 diabetes, this medication can provide a helpful solution to improve blood sugar control and support a healthy lifestyle.

How Does Mounjaro KwikPen Work?

Mounjaro works by mimicking two naturally occurring hormones that influence blood sugar control:

1. GIP (Glucose-Dependent Insulinotropic Polypeptide) and
2. GLP-1 (Glucagon-Like Peptide-1).

These hormones help the body manage blood sugar in three key ways:

• Increased Insulin Release: When your blood sugar levels are high, Mounjaro helps your body produce more insulin to bring those levels down.
• Reduced Sugar Production: Mounjaro lowers the amount of sugar produced by your liver, helping to prevent spikes in blood sugar.
• Slowed Digestion: Mounjaro slows down how quickly food moves through your stomach. This delay can help control blood sugar levels after meals and may also help you feel fuller for longer, which can support weight management.

Getting Started with Mounjaro KwikPen

Your doctor will start you on a low dose to help your body adjust. Here’s how the process typically works:

1. Starting Dose: The usual starting dose is 2.5 mg once a week, injected under the skin.
2. Increasing the Dose: After four weeks, your doctor may increase the dose to 5 mg per week if additional blood sugar control is needed.
3. Maximum Dose: If necessary, your doctor may further increase your dose in 2.5 mg increments up to a maximum of 15 mg once weekly. Always follow the dosage instructions provided by your healthcare provider.

Using Your Mounjaro KwikPen

Each Mounjaro KwikPen contains four doses, so it lasts one month. Here are some important steps to follow when using it:

• Preparation: Before each injection, check that the solution in the pen is clear and colorless to slightly yellow. If you notice any particles or discoloration, do not use the pen.
• Injection Sites: Mounjaro is injected under the skin of your stomach, thigh, or upper arm. It’s essential to rotate your injection site with each dose to avoid irritation.
• Timing: You can take Mounjaro at any time of day, with or without food. Try to stick to the same day each week for your dose.

If you’re also using insulin, inject Mounjaro and insulin in separate areas of the body, at least an inch apart. Never mix the two medications in one injection.

Dosage Chart

Here’s a dosage chart for the Mounjaro KwikPen, detailing the dosage progression typically recommended for patients, as well as the weekly administration plan.

Notes:

• Administration: Each dose is administered once a week on the same day each week.
• Injection Sites: Inject in the abdomen, thigh, or upper arm, rotating the injection site each week.
• Pen Use: The multi-dose pen is designed to deliver four weekly doses, so each pen lasts approximately one month (28 days).
• Missed Doses: If a dose is missed, it can be administered within four days (96 hours). If more than four days have passed, skip that dose and resume the regular schedule.

This chart is a general guideline; specific dosing instructions should be personalized based on individual medical needs and provided by a healthcare provider.

What if I Miss a Dose?

If you miss a dose, take it as soon as possible within four days (96 hours) of the missed dose. If more than four days have passed, skip the missed dose entirely and take your next dose on your regular schedule. If you ever need to change your weekly dose day, make sure that there are at least three days (72 hours) between doses.

Storage Tips for Mounjaro KwikPen

• Refrigeration: Store the pen in a refrigerator between 35°F to 46°F. Do not freeze it.
• Unrefrigerated Storage: If needed, you can store the pen at room temperature (no higher than 86°F) for up to 30 days.
• Light Protection: Keep Mounjaro KwikPen in its original carton to protect it from light.
• After Use: Once you have completed the four doses, discard the pen in a puncture-resistant container, following local guidelines for safe disposal.

Important Safety Information

While Mounjaro KwikPen can offer many benefits, it’s important to be aware of some potential risks and side effects.

Common Side Effects

Most people may experience mild side effects, especially during the first few weeks as the body adjusts. These include:

• Nausea: This is one of the most common side effects, especially with higher doses.
• Vomiting and Diarrhea: These can occur initially but usually decrease over time.
• Decreased Appetite: Some people may find they feel fuller sooner or don’t get as hungry, which can contribute to weight loss.

If these side effects persist or worsen, let your doctor know.

Serious Warnings

Mounjaro KwikPen has some serious warnings:

• Thyroid Cancer Risk: Mounjaro has been linked to an increased risk of thyroid tumors in animal studies. If you or any family member has a history of a specific type of thyroid cancer (medullary thyroid carcinoma) or a condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), do not use Mounjaro.
• Pancreatitis: Some users of Mounjaro have reported inflammation of the pancreas. Symptoms can include severe stomach pain that may spread to the back, nausea, or vomiting. Contact your doctor if you experience these symptoms.

Other possible side effects include low blood sugar, especially if taken with other medications like insulin or sulfonylureas. Talk to your doctor about monitoring your blood sugar to avoid this.

Monitoring and Follow-Up

Your doctor will likely want to monitor your progress with periodic blood tests, especially HbA1c, to ensure that your blood sugar levels are being managed effectively. Regular check-ups also allow your doctor to adjust your dose if needed and to check for any side effects or potential complications.

Questions or Concerns?

It’s always okay to reach out to your healthcare provider with any questions or if something doesn’t feel right. Mounjaro KwikPen is a helpful tool in managing type 2 diabetes, and your healthcare team is there to support you every step of the way.

Reference: Mounjaro Canada product monograph

Advantages of Mounjaro KwikPen vs. Mounjaro Vials

The Mounjaro KwikPen offers several advantages over vials, particularly in terms of convenience and ease of use. The KwikPen is pre-filled and designed for simple self-injection, making it much easier for patients, especially those with limited dexterity. Unlike vials, which require each dose to be drawn up with a syringe, the KwikPen provides pre-measured doses, reducing the risk of dosing errors and simplifying the weekly injection process. In addition, the KwikPen is more compact and portable, which makes it ideal for patients who travel or need a discreet option for their medication. Unlike vials, which require separate syringes and additional packaging for travel, the KwikPen requires no extra supplies, making storage and transport more convenient.

Another benefit of the KwikPen is reduced waste and potential cost savings. Because each KwikPen contains multiple doses, it results in less packaging waste compared to single-use vials. Fewer supplies, such as syringes and alcohol swabs, are needed, potentially reducing overall costs. Additionally, the KwikPen is designed for greater comfort during injection. With a fine needle, it minimizes discomfort and allows flexibility in injection sites, including the abdomen, thigh, or upper arm. In contrast, vials require the additional step of syringe preparation, which may feel more complex or intimidating.

The KwikPen also has a lower risk of contamination due to its self-contained design. Patients only need to attach a new needle each time, maintaining sterility throughout its use, whereas vials require manual handling and preparation, which can increase the risk of contamination. Overall, the Mounjaro KwikPen streamlines the injection process, enhances patient experience, and helps maintain adherence to the prescribed regimen, making it an ideal choice for many patients.