Xeljanz (Tofacitinib)
Xeljanz (Tofacitinib)
Tofacitinib
Product information
Xeljanz (tofacitinib) is an oral medication used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis in adults who haven't responded to other treatments. It works by reducing immune system activity to lessen inflammation. Common side effects include infections, headaches, and increased cholesterol. Serious risks include infections, liver problems, and cancer. Regular monitoring by a doctor is essential during treatment. Avoid if pregnant or with severe liver issues.
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Xeljanz - Canada Product Information
What is Xeljanz?
Xeljanz is a prescription medicine used to treat adults with:
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Rheumatoid Arthritis (RA): This is a condition where your immune system mistakenly attacks your joints, causing pain and swelling. Xeljanz helps reduce the symptoms of RA in people who haven’t responded well to methotrexate or cannot tolerate it.
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Psoriatic Arthritis (PsA): This is a condition that causes joint pain and swelling in people who have psoriasis. Xeljanz is used in combination with other medications like methotrexate to help manage PsA symptoms.
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Ulcerative Colitis (UC): Xeljanz is used to treat moderate to severe UC in adults who have not responded well to other treatments.
How Does Xeljanz Work?
Xeljanz works by targeting and blocking certain enzymes in your body that are involved in inflammation. By doing this, it helps to reduce the activity of your immune system, which can prevent it from attacking your own body.
How to Take Xeljanz
- Dosage: Follow your doctor’s instructions on how to take Xeljanz. It is typically taken by mouth, with or without food.
- Do not crush, chew, or break the tablet. Swallow it whole with water.
Important Warnings
- Infections: Xeljanz can lower your immune system's ability to fight infections. You may be more likely to get serious infections such as tuberculosis, fungal infections, and viral infections. Inform your doctor if you experience symptoms like fever, cough, or unusual tiredness.
- Cancer Risks: Some patients taking Xeljanz have developed cancers, including lymphomas and skin cancer. Your doctor will monitor you for any signs of these conditions.
- Liver Problems: Xeljanz can affect your liver. Your doctor will check your liver function regularly during treatment.
Who Should Not Take Xeljanz?
Do not take Xeljanz if you:
- Are allergic to tofacitinib or any of its ingredients.
- Are pregnant or planning to become pregnant.
- Have severe liver problems.
Possible Side Effects
Common side effects include:
- Upper respiratory infections: like the common cold.
- Headache
- Diarrhea
- Increased cholesterol levels
Serious side effects include:
- Serious infections
- Liver problems
- Increased risk of cancer
If you notice any signs of infection, liver problems (like yellowing of the skin or eyes), or unusual symptoms, contact your doctor immediately.
Monitoring and Tests
While you are taking Xeljanz, your doctor will need to monitor your health regularly. This includes blood tests to check your liver function, cholesterol levels, and immune system.
What Should I Tell My Doctor?
Before starting Xeljanz, tell your doctor if you:
- Have any infections or symptoms of infection.
- Have a history of liver problems, kidney problems, or heart disease.
- Have been vaccinated recently or are planning to get a vaccine.
Storage Instructions
Store Xeljanz at room temperature, away from moisture and heat. Keep out of reach of children.
What If I Miss a Dose?
If you miss a dose of Xeljanz, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time.
This summarizes the key information about Xeljanz. Always follow your doctor’s instructions and ask them if you have any questions about your treatment.
Reference: Xeljanz/Xeljanz XR Canada product monograph