Zepbound (Tirzepatide)

SAVE on ZEPBOUND ordering online from Canada! (USA Prescription Required)

Important: Submit your American Zepbound prescription, and our Canadian physician will seamlessly convert it to Mounjaro (tirzepatide), which contains the same active ingredient. This allows you to continue receiving your medication affordably. For more information, contact our team via email at support@drugsbycanada.com, phone at 1-888-349-5925, or live chat.

ZEPBOUND (Tirzepatide) Injection - Canada Product Information

---

NOTICE: In Canada, Zepbound is marketed under the name Mounjaro, please follow the link to process your order. In Canada, Zepbound/Mounjaro is dispensed as a single use vial. Each vial is only to be used once and is equivalent to one week (7 days) of medication. Four (4) vials should be ordered for a 28 days supply. Vials are shipped in a ziploc bag, with 2 alcohol swabs and one syringe per vial ordered. A video demonstration on administering Zepbound/Mounjaro from Canada can be found here. Patients in Delaware, Tennessee, Florida, or the Virgin Islands will require a prescription for diabetic syringes as well.

This differs from the United States where Zepbound is dispensed as a single dose pen.

WHAT IS ZEPBOUND?

ZEPBOUND is a medication used to help manage weight in adults. It works best when combined with a reduced-calorie diet and increased physical activity.

WHO CAN USE ZEPBOUND?

ZEPBOUND is for adults with:

• A Body Mass Index (BMI) of 30 or greater (obesity)
• A BMI of 27 or greater (overweight) with at least one weight-related health issue such as high blood pressure, high cholesterol, type 2 diabetes, sleep apnea, or heart disease.

IMPORTANT SAFETY INFORMATION

WARNING: RISK OF THYROID TUMORS

• In animal studies, ZEPBOUND caused thyroid tumors. It's unclear if it causes thyroid tumors in humans.
• Do not use ZEPBOUND if you or your family have a history of thyroid cancer or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).

HOW TO USE ZEPBOUND

• Start with a dose of 2.5 mg injected under the skin once a week.
• After 4 weeks, increase to 5 mg once a week.
• If needed, the dose can be increased by 2.5 mg increments every 4 weeks.
• The maintenance doses are 5 mg, 10 mg, or 15 mg once a week, with a maximum of 15 mg per week.
• Inject ZEPBOUND in the abdomen, thigh, or upper arm, and rotate injection sites each time. A video of how to inject Canadian ZEPBOUND can be found here

DOSAGE

ZEPBOUND dosage chart:

Week	Dose (mg)	Notes
Week 1-4	2.5 mg	Starting dose, not for long-term use
Week 5-8	5 mg	Increase to 5 mg if well-tolerated
Week 9-12	7.5 mg	Increase to 7.5 mg if needed and well-tolerated
Week 13-16	10 mg	Increase to 10 mg if needed and well-tolerated
Week 17 and beyond	Up to 15 mg	Increase by 2.5 mg increments every 4 weeks as needed, maximum dose is 15 mg

WHO SHOULD NOT USE ZEPBOUND?

Do not use ZEPBOUND if you:

• Have a personal or family history of thyroid cancer or MEN 2.
• Have had a severe allergic reaction to tirzepatide or any ingredients in ZEPBOUND.

POSSIBLE SIDE EFFECTS

Common side effects include:

• Nausea, vomiting, diarrhea, constipation
• Abdominal pain, indigestion
• Fatigue, reactions at the injection site
• Hypersensitivity reactions (like rash, itching)
• Increased heart rate
• Hair loss

Serious side effects:

• Thyroid tumors
• Severe gastrointestinal issues
• Acute kidney injury
• Gallbladder problems
• Pancreatitis (inflammation of the pancreas)
• Low blood sugar (hypoglycemia)
• Diabetic retinopathy (eye problems)
• Suicidal thoughts and behavior

MISSED DOSE

If you miss a dose, take it as soon as possible within 4 days. If more than 4 days have passed, skip the missed dose and take the next dose on your regular day.

DIETARY RESTRICTIONS

There are no specific dietary restrictions while taking ZEPBOUND. However, to achieve effective weight management, it is recommended to follow a reduced-calorie diet. Aim to create a calorie deficit by consuming fewer calories than you burn. Focus on a balanced diet that includes a variety of fruits, vegetables, lean proteins, and whole grains, while limiting sugary snacks, beverages, and high-fat foods. Staying hydrated by drinking plenty of water throughout the day is also essential. Additionally, eating regular meals and avoiding skipping them helps maintain steady blood sugar levels. For personalized dietary advice while on ZEPBOUND, always consult your healthcare provider.

SPECIAL CONSIDERATIONS

Pregnancy and Breastfeeding: Do not use ZEPBOUND if you are pregnant. It is not known if ZEPBOUND passes into breast milk.

Kidney and Liver Issues: No dose adjustments are needed, but monitor for adverse reactions.

HOW TO STORE ZEPBOUND

Store in the refrigerator. If needed, it can be kept at room temperature for up to 4 weeks.

Consult your doctor for more details and to see if ZEPBOUND is right for you. They can provide guidance on diet, exercise, and how to properly use this medication.

This provides essential information about ZEPBOUND in a patient-friendly manner. Always refer to your healthcare provider for personalized advice and information.

---

Reference: Zepbound USA product monograph

---

Comparing ZEPBOUND and Wegovy: Advantages of ZEPBOUND

When it comes to managing obesity and overweight conditions, two prominent medications often come into the spotlight: ZEPBOUND (tirzepatide) and Wegovy (semaglutide). While both are effective, ZEPBOUND offers several distinct advantages that might make it a preferable choice for some patients.

Firstly, ZEPBOUND targets two receptors—GIP and GLP-1—whereas Wegovy targets only the GLP-1 receptor. This dual mechanism of action in ZEPBOUND can lead to more comprehensive management of weight by influencing both appetite regulation and insulin secretion. Studies suggest that the combination of these pathways can enhance the overall effectiveness of weight reduction.

Another advantage of ZEPBOUND is its flexibility in dosing. Starting at 2.5 mg and going up to 15 mg, ZEPBOUND allows for gradual dose adjustments based on patient tolerance and response. This titration schedule can help minimize side effects like nausea and gastrointestinal discomfort, which are common with weight loss medications.

Moreover, ZEPBOUND has shown significant results in clinical trials, with patients experiencing substantial reductions in body weight and improvements in related health conditions such as high blood pressure, dyslipidemia, and type 2 diabetes. These broad-spectrum benefits make it a robust option for comprehensive weight management.

In summary, ZEPBOUND’s dual-receptor approach, flexible dosing, and significant clinical outcomes provide a compelling advantage over Wegovy, making it a strong candidate for those seeking effective and tailored weight management solutions.

---

How Effective is ZEPBOUND for Weight Loss?

ZEPBOUND (tirzepatide) is a new medication designed to help with weight management by targeting two specific receptors in the body, GIP and GLP-1. These receptors help regulate appetite and improve insulin secretion, making ZEPBOUND a comprehensive tool for weight loss.

Key Clinical Studies

Two major clinical trials have shown how effective ZEPBOUND is for weight loss. These trials involved adults who were either obese or overweight with other health conditions like high blood pressure, high cholesterol, sleep apnea, or heart disease.

Study 1 (NCT04184622):

In the first study, over 2,500 adults participated. They had a Body Mass Index (BMI) of 30 or higher, or 27 or higher with at least one weight-related health issue. Participants took either a placebo or ZEPBOUND in doses of 5 mg, 10 mg, or 15 mg once a week for 72 weeks. Those taking the highest dose of ZEPBOUND (15 mg) saw an average weight reduction of 20.9%. Impressively, 90.9% of these participants lost at least 5% of their body weight. They also experienced improvements in waist size, blood pressure, and cholesterol levels.

Study 2 (NCT04657003):

The second study included nearly 1,000 adults who had a BMI of 27 or higher and type 2 diabetes. Like the first study, participants took either a placebo or ZEPBOUND in doses of 10 mg or 15 mg once a week. Those on the highest dose lost an average of 14.7% of their body weight. Additionally, they saw significant improvements in their blood sugar levels, which is crucial for managing diabetes.

Summary

These studies show that ZEPBOUND is highly effective for weight loss, helping people lose a significant amount of weight and improving their overall health. By targeting both appetite and insulin secretion, ZEPBOUND offers a powerful solution for those struggling with obesity and related health issues. If you are looking for a comprehensive weight management option, ZEPBOUND could be an excellent choice. Always consult your healthcare provider to see if ZEPBOUND is right for you.

To use Zepbound (marketed in Canada as Mounjaro vials), inject the prescribed dose subcutaneously (under the skin) in the abdomen, thigh, or upper arm once weekly. Use a new syringe for each injection. Rotate injection sites to avoid irritation. Check the solution; it should be clear and colorless. Do not use if discolored or contains particles. Follow your healthcare provider's instructions on proper injection technique and dosage adjustments.