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Entresto (sacubitril/valsartan) - Canada Product Information
Entresto is a combination medication containing sacubitril and valsartan. It is used to treat heart failure by helping your heart pump blood more effectively. Sacubitril works by increasing the levels of certain proteins that help relax blood vessels, while valsartan blocks the action of a substance that tightens blood vessels.
HOW TO TAKE ENTRESTO
Take Entresto exactly as prescribed by your doctor.
It is usually taken twice daily, about 12 hours apart.
Can be taken with or without food, but try to take it at the same times each day to
maintain an even level in your blood.
WHY YOU MIGHT NEED ENTRESTO
Indication: Entresto is used to treat chronic heart failure with reduced ejection fraction, a condition where the heart doesn't pump blood as well as it should.
Improved Heart Function: Helps improve your heart's ability to pump blood.
Reduced Symptoms: Can help reduce symptoms like shortness of breath, swelling in
your legs, and fatigue.
AVAILABLE DOSES OF ENTRESTO FROM CANADA
24 mg sacubitril / 26 mg valsartan: For patients starting treatment or those who need a
lower dose due to certain medical conditions.
49 mg sacubitril / 51 mg valsartan: Common starting dose for many patients.
97 mg sacubitril / 103 mg valsartan: Maximum dose for patients who tolerate the
medication well and need stronger effects.
BENEFITS OF ENTRESTO VS OTHER OPTIONS
Improved Outcomes: Studies show Entresto reduces risk of
hospitalization and death from heart failure compared to traditional treatments like ACEI's or ARBs alone.
Symptom Relief: Many patients report feeling better and having more energy while on
Entresto.
Better Quality of Life: Patients often experience an improved quality of life due to fewer
heart failure symptoms and hospitalizations.
POSSIBLE SIDE EFFECTS
Common Side Effects:
Low Blood Pressure: You might feel dizzy or lightheaded, especially when
standing up quickly.
High Potassium Levels: This can lead to weakness, fatigue, and irregular
heartbeats.
Kidney Function Changes: Your doctor will monitor your kidney function with
blood tests.
Cough: A persistent cough can occur in some patients.
Serious Side Effects:
Angioedema: Swelling of the face, lips, tongue, or throat which can be serious
and requires immediate medical attention.
Severe Allergic Reactions: Rash, itching, severe dizziness, and trouble breathing.
PRECAUTIONS
Pregnancy: Do not use if you are pregnant or planning to become pregnant. Entresto can
harm an unborn baby.
History of Angioedema: Avoid if you have had angioedema (swelling) related to
previous ACE inhibitor or ARB therapy.
Kidney or Liver Problems: Inform your doctor if you have kidney or liver issues before
starting Entresto.
WHEN TO CONTACT YOUR DOCTOR
Severe Side Effects: If you experience swelling, difficulty breathing, or severe dizziness,
seek medical attention immediately.
Worsening Symptoms: If your heart failure symptoms worsen, such
as increased shortness of breath, swelling in the legs, or rapid weight gain.
ADDITIONAL INFORMATION
Follow Instructions: Always take Entresto as directed by your healthcare provider.
Do Not Stop Suddenly: Do not stop taking Entresto without consulting your doctor, as
this can worsen your condition.
Regular Check-ups: Regular follow-ups with your doctor are important to monitor your
condition and adjust the dose if needed.
CONTACT US
For More Information: Contact us at DrugsByCanada for more information on how to
purchase Entresto from Canada.
Reference -
Entresto Canada product monograph