Linzess (Constella – Linaclotide)

SAVE on LINZESS (Constella - Linaclotide) ordering online from Canada! (USA Prescription Required)

LINZESS (Constella - Linaclotide) - Canada Product Information

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IMPORTANCE NOTICE: Linzess is marketed in Canada under the name Constella.

Linzess (linaclotide) is a medication that comes in capsule form, used to treat two specific conditions in adults:

Irritable Bowel Syndrome with Constipation (IBS-C)

Chronic Idiopathic Constipation (CIC)

How does Linzess work?

Linzess helps increase fluid in your intestines, which can make bowel movements easier and help reduce the symptoms of abdominal pain, bloating, and discomfort associated with IBS-C and CIC.

How to take Linzess

Dosage for IBS-C: Take 290 mcg (one capsule) once daily on an empty stomach, at least 30 minutes before your first meal.

Dosage for CIC: Take 145 mcg (one capsule) once daily on an empty stomach, at least 30 minutes before your first meal. Some patients may be prescribed a lower dose of 72 mcg based on their needs.

Instructions for taking Linzess

1. Take the capsule whole. Do not chew it.
2. If you have trouble swallowing, you can mix the contents of the capsule with applesauce or water:
   • For applesauce: Open the capsule and sprinkle the beads on one teaspoon of room-temperature applesauce. Swallow immediately without chewing.
   • For water: Open the capsule and sprinkle the beads into 30 mL of room-temperature bottled water. Swirl for at least 20 seconds and drink immediately. Repeat with another 30 mL of water if beads remain.

Missed Dose

If you miss a dose, skip it and take your next dose at the regular time. Do not take two doses at once.

Who should not take Linzess ?

Children under 6 years old (and it is not recommended for those aged 6 to 18 years).

Anyone allergic to linaclotide or any other ingredients in the medication.

Patients with known or suspected gastrointestinal obstruction.

Possible Side Effects

Common side effects include:

Diarrhea (most common)

Abdominal pain

Gas

Bloating

If you experience severe diarrhea, stop taking Linzess and contact your healthcare provider.

Special Considerations

Pregnancy: There are no well-controlled studies in pregnant women. Use only if the potential benefit justifies the potential risk to the fetus.

Breastfeeding: Linzess is minimally absorbed and not expected to affect the breastfed child. Consult your doctor for more information.

Older Adults: The safety and effectiveness for those over 65 years have not been well studied. Consult your doctor if you are in this age group.

Storage

Store at room temperature

Keep the medication in its original container with the desiccant inside to protect from moisture.

Keep the container tightly closed and out of reach of children.

Supplied

Linzess is prescribed under the name Constella in Canada. The strengths 72, 145, and 290 mg are available in bottles of 30 capsules labelled Constella.

This leaflet is a summary and does not contain all possible information about Linzess. Always follow your healthcare provider's instructions and read the information provided with the medication.

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Reference: Constella Canada product monograph

Product Video: Canadian Linzess

Take Linzess (linaclotide) once daily on an empty stomach, at least 30 minutes before your first meal. Swallow the capsule whole; do not chew. If you have trouble swallowing, you can mix the capsule contents with applesauce or water. If you miss a dose, skip it and take the next one as scheduled. Do not take two doses at once.