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Cuprimine (Penicillamine) for Veterinary Use: Fact Table

Category Details
Generic Name Penicillamine
Brand Name Cuprimine
Veterinary Use Used primarily for treating copper storage diseases and sometimes for immune-mediated conditions in dogs and cats
Form Oral capsules or tablets
Strengths Available Typically 250 mg capsules/tablets
Mechanism of Action Binds to copper and promotes its excretion in urine, also has immune-modulating properties
Indications – Copper storage disease (e.g., in Bedlington Terriers)
  – Wilson’s disease in animals (rare)
  – Rheumatoid-like arthritis in dogs (off-label)
  – Systemic lupus erythematosus in dogs (off-label)
Dosage Varies by condition and species; typically prescribed by a veterinarian based on weight and severity of condition
Administration Oral; given with or without food as directed by a veterinarian
Side Effects – Loss of appetite
  – Vomiting
  – Diarrhea
  – Skin rashes or itching
  – Proteinuria (excess protein in urine)
  – Potential for bone marrow suppression (rare)
Contraindications – Known hypersensitivity to penicillamine
  – Severe renal impairment
Monitoring Regular blood tests (complete blood count, liver and kidney function tests) and urine tests are recommended during treatment
Drug Interactions – Antacids (may reduce absorption)
  – Iron supplements (may reduce effectiveness)
Special Precautions – Should be used with caution in animals with a history of bone marrow suppression or kidney disease
Withdrawal Period Not applicable as Cuprimine is not typically used in food-producing animals
Storage Store at room temperature, away from moisture and light
Legal Status Prescription only (Rx)
Manufacturer Produced by various manufacturers

This fact table provides a comprehensive overview of Cuprimine (penicillamine) for veterinary use, focusing on its application for treating conditions like copper storage disease and other off-label uses in dogs and cats. Always consult a veterinarian for specific treatment and dosage guidelines tailored to your pet’s needs.